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| OLIVEIRA,CARLOS H.M.; SIMÃO,ANDERSON A.; TRENTO,MARCUS V.C.; CÉSAR,PEDRO H.S.; MARCUSSI,SILVANA. |
| ABSTRACT The enzyme inhibition by natural and/ or low-cost compounds may represent a valuable adjunct to traditional serotherapy performed in cases of snakebite, mainly with a view to mitigate the local effects of envenoming. The objective of this study was to evaluate possible interactions between vitamins and enzymes that comprise Bothrops atrox and Crotalus durissus terrificus venoms, in vitro. Proteolysis inhibition assays (substrates: azocasein, collagen, gelatin and fibrinogen), hemolysis, coagulation, hemagglutination were carried out using different proportions of vitamins in face of to inhibit minimum effective dose of each venom. The vitamins were responsible for reducing 100% of breaking azocasein by C.d.t. venom, thrombolysis induced by B.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antiophidian properties; Antioxidants; Blood cells; Hemostatic processes; Natural inhibitors. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000502005 |
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| Fernandes,RS; Costa,TR; Marcussi,S; Bernardes,CP; Menaldo,DL; Rodriguéz Gonzaléz,II; Pereira,PS; Soares,AM. |
| Most of the snakebites recorded in Brazil are caused by the Bothrops genus. Given that the local tissue damage caused by this genus cannot be treated by antivenom therapy, numerous studies are focusing on supplementary alternatives, such as the use of medicinal plants. Serjania erecta has already demonstrated anti-inflammatory, antiseptic and healing properties. In the current study, the aerial parts of S. erecta were extracted with methanol, then submitted to chromatographic fractionation on a Sephadex LH20 column and eluted with methanol, which resulted in four main fractions. The crude extract and fractions neutralized the toxic activities of Bothrops jararacussu snake venom and isolated myotoxins (BthTX-I and II). Results showed that phospholipase A2,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Medicinal plants; Antiophidian properties; Serjania erecta; Bothrops jararacussu snake venom; Myotoxins. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000100011 |
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